Psychopharmacology Unit (PPU)

Kamal K. Midha.: Publications of the last 10 years.

Midha KK; Rawson MJ; Hubbard JW. Individual and average bioequivalence of highly variable drugs and drug products. Journal of Pharmaceutical Sciences, 1997 Nov, 86(11):1193-7.

Luo JP; Hubbard JW; Midha KK. Studies on the mechanism of absorption of depot neuroleptics: fluphenazine decanoate in sesame oil. Pharmaceutical Research, 1997 Aug, 14(8):1079-84.

Yan J; Hubbard JW; McKay G; Midha KK. Stereoselective and simultaneous measurement of cis- and trans-isomers of doxepin and N-desmethyldoxepin in plasma or urine by high-performance liquid chromatography. Journal of Chromatography. B, Biomedical Applications, 1997 Mar 28, 691(1):131-8.

Tugnait M; Hawes EM; McKay G; Rettie AE; Haining RL; Midha KK. N-oxygenation of clozapine by flavin-containing monooxygenase. Drug Metabolism and Disposition, 1997 Apr, 25(4):524-7.

Luo JP; Hubbard JW; Midha KK. Sensitive method for the simultaneous measurement of fluphenazine decanoate and fluphenazine in plasma by high-performance liquid chromatography with coulometric detection. Journal of Chromatography. B, Biomedical Applications, 1997 Jan 24, 688(2):303-8.

Zhang GO; McKay G; Hubbard JW; Midha KK. Application of electrospray mass spectrometry in the identification of intact glucuronide and suplate conjugates of clozapine in rat. Xenobiotica, 1996 May, 26(5):541-50.

Lin G; McKay G; Midha KK. Characterization of metabolites of clozapine N-oxide in the rat by micro-column high performance liquid chromatography/mass spectrometry with electrospray interface. Journal of Pharmaceutical and Biomedical Analysis, 1996 Aug, 14(11):1561-77.

Barbhaiya RH; Shukla UA; Greene DS; Breul HP; Midha KK. Investigation of pharmacokinetic and pharmacodynamic interactions after coadministration of nefazodone and haloperidol. Journal of Clinical Psychopharmacology, 1996 Feb, 16(1):26-34.

Muralidharan G; Cooper JK; Hawes EM; Korchinski ED; Midha KK. Quinidine inhibits the 7-hydroxylation of chlorpromazine in extensive metabolisers of debrisoquine. European Journal of Clinical Pharmacology, 1996, 50(1-2):121-8.

Hadad S; Hubbard JW; McKay G; Hawes EM; Shrikhande S; Midha KK. Evidence for the lack of a human metabolic isotope effect of a deuterium analog of fluphenazine. Pharmaceutical Research, 1995 Sep, 12(9):1388-90.

He H; McKay G; Midha KK. Phase I and II metabolites of benztropine in rat urine and bile. Xenobiotica, 1995 Aug, 25(8):857-72.

Aravagiri M; Marder SR; Yuwiler A; Midha KK; Kula NS; Baldessarini RJ. Distribution of fluphenazine and its metabolites in brain regions and other tissues of the rat. Neuropsychopharmacology, 1995 Nov, 13(3):235-47.

Hadad S; Hubbard JW; McKay G; Hawes EM; Shrikhande S; Midha KK.Evidence for the lack of a human metabolic isotope effect of a deuterium analog of fluphenazine. Pharmaceutical Research, 1995 Sep, 12(9):1388-90.

He H; McKay G; Midha KK. Phase I and II metabolites of benztropine in rat urine and bile. Xenobiotica, 1995 Aug, 25(8):857-72.


He H; McKay G; Wirshing B; Midha KK. Development and application of a specific and sensitive radioimmunoassay for trihexyphenidyl to a pharmacokinetic study in humans. Journal of Pharmaceutical Sciences, 1995 May, 84(5):561-7.

Luo H; Hawes EM; McKay G; Korchinski ED; Midha KK. N(+)-glucuronidation of aliphatic tertiary amines in human: antidepressant versus antipsychotic drugs. Xenobiotica, 1995 Mar, 25(3):291-301.

Goff DC; Midha KK; Sarid-Segal O; Hubbard JW; Amico E. A placebo-controlled trial of fluoxetine added to neuroleptic in patients with schizophrenia. Psychopharmacology, 1995 Feb, 117(4):417-23.

Lin G; McKay G; Hubbard JW; Midha KK. Decomposition of clozapine N-oxide in the qualitative and quantitative analysis of clozapine and its metabolites. Journal of Pharmaceutical Sciences, 1994 Oct, 83(10):1412-7.

Midha KK; Hubbard JW; Marder SR; Marshall BD; Van Putten T. Impact of clinical pharmacokinetics on neuroleptic therapy in patients with schizophrenia. Journal of Psychiatry and Neuroscience, 1994 Jul, 19(4):254-64.

Luo H; McKay G; Midha KK. Identification of clozapine N(+)-glucuronide in the urine of patients treated with clozapine using electrospray mass spectrometry. Biological Mass Spectrometry, 1994 Mar, 23(3):147-8.

He H; McKay G; Midha KK. Development of a sensitive and specific radioimmunoassay for benztropine.Journal of Pharmaceutical Sciences, 1993 Oct, 82(10):1027-32.

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